Alexander (Sasha) Gusev is a computational biologist and an Assistant Professor of Medicine at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

Research and career

Alexander Gusev has developed computational methods that use genetic data to decipher disease mechanisms. For example, he has identified 34 new genes associated with increased risk of earliest-stage ovarian cancer. He has developed computational methods that integrate molecular data to facilitate functional interpretation of findings from

genome-wide association studies In genomics, a genome-wide association study (GWA study, or GWAS), also known as whole genome association study (WGA study, or WGAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any varia ...

. He has contributed to the development of the

transcriptome-wide association study Transcriptome-wide association study (TWAS) is a statistical genetics methodology to improve detection power and provide functional annotation for genetic associations with phenotypes by integrating single-nucleotide polymorphism to trait (SNP-t ...

approach to mapping disease-associated genes. In addition, he studies the interactions between

germline In biology and genetics, the germline is the population of a multicellular organism's cells that pass on their genetic material to the progeny (offspring). In other words, they are the cells that form the egg, sperm and the fertilised egg. They ...

(host) and somatic events (tumor) - which are typically studied separately - and their effects on cancer progression and treatment response to advance precision oncology.

Awards and honors

* Claudia Adams Barr Award, 2017-2019 * Ruth L. Kirschstein National Research Service Award 2013-2015

Selected publications

* Integrative approaches for large-scale transcriptome-wide association studies. A Gusev, A Ko, H Shi, G Bhatia, W Chung, B Penninx, R Jansen, E Geus, et al. ''Nature Genetics''. 48(3):245–252. doi:10.1038/ng.3506 * Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. A Gusev, N Mancuso, H Won, M Kousi, HK Finucane, Y Reshef, L Song, et al. ''Nature Genetics''. 50(4):538-548. doi:10.1038/s41588-018-0092-1 * Quantifying genetic effects on disease mediated by assayed gene expression levels.Yao DW, O'Connor LJ, Price AL, Gusev A. ''Nature Genetics''. 52(6):626-633. doi:10.1038/s41588-020-0625-2 * Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms. Shetty A, Seo JH, Bell CA, O'Connor EP, Pomerantz MM, Freedman ML, Gusev A. ''The American Journal of Human Genetics''. 108(11):2071-2085. doi:10.1016/j.ajhg.2021.09.008 * Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation. A Gusev, H Shi, G Kichaev, M Pomerantz, F Li et al. ''Nature Communications''. doi:10.1038/ncomms10979 * Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. A Gusev, SH Lee, G Trynka, H Finucane et al. ''The American Journal of Human Genetics''. 95(5):535-52. doi:10.1016/j.ajhg.2014.10.004 * Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations. J Carrot-Zhang, G Soca-Chafre, N Patterson,..., A Gusev, M Meyerson. ''Cancer Discovery''. 11(3):591-598. doi:10.1158/2159-8290.CD-20-1165

References

External links

* {{DEFAULTSORT:Gusev, Alexander Geneticists Statistical_geneticists Columbia University alumni Harvard Medical School people Year of birth missing (living people) Living people